Recombinant Hepatitis B virus genotype D Protein X (X), Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D), E.coli, N-terminal 6xHis-SUMO-tagged, 32.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Hepatitis B virus genotype D Protein X (X)

Recombinant Hepatitis B virus genotype D Protein X (X) — Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Purity >90%.

SKU: BCRECP-004753 Categories: , ,
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Product Specifications

Product SkuBCRECP-004753
Product DescriptionRecombinant Hepatitis B virus genotype D Protein X (X) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-154aa. [Accession | O93195].
Uniprot No.O93195
Gene NamesX
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-154aa
SpeciesHepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight32.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).

Biological Context

Subcellular Location: Host cytoplasm; Host nucleus; Host mitochondrion

Product Specifications

Recombinant Hepatitis B virus genotype D Protein X (X) is a recombinant protein from Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D), expressed in E.coli, covering amino acids 1-154aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 32.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT

Subcellular Location

Host cytoplasm; Host nucleus; Host mitochondrion

Subunit

May form homodimer. May interact with host CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4. Interacts with host SMC5-SMC6 complex and induces its degradation. Interacts with host TRPC4AP; leading to prevent ubiquitination of TRPC4AP. Interacts with host PLSCR1; this interaction promotes ubiquitination and degradation of HBx and impairs HBx-mediated cell proliferation

Gene: X  |  Organism: Hepatitis B virus genotype D (isolate Germany/1-91/1991)  |  Synonyms: HBx; Peptide X; pX

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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