Recombinant Human 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 47.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)

Recombinant Human 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) — Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs). Purity >90%.

SKU: BCRECP-000008 Category:
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Product Specifications

Product SkuBCRECP-000008
Product DescriptionRecombinant Human 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 27-331aa. [Accession | P09110].
Uniprot No.P09110
Gene NamesACAA1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region27-331aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight47.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs). Plays an important role in fatty acid peroxisomal beta-oxidation. Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs.

Biological Context

Subcellular Location: Peroxisome
Pathway: Lipid metabolism; peroxisomal fatty acid beta-oxidation

Product Specifications

Recombinant Human 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 27-331aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 47.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes

Subcellular Location

Peroxisome

Subunit

Homodimer (Ref.19). Interacts (via PTS2-type peroxisomal targeting signal region) with PEX7; leading to its translocation into peroxisomes (PubMed:22057399, PubMed:25538232)

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation

Gene: ACAA1  |  Organism: Homo sapiens  |  Synonyms: Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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