Recombinant Human 5-hydroxytryptamine receptor 1D (HTR1D), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-KSI-tagged, 19.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human 5-hydroxytryptamine receptor 1D (HTR1D), partial

Recombinant Human 5-hydroxytryptamine receptor 1D (HTR1D), partial — G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Purity >85%.

SKU: BCRECP-000868 Category:
Online Inquiry →

Product Specifications

Product SkuBCRECP-000868
Product DescriptionRecombinant Human 5-hydroxytryptamine receptor 1D (HTR1D) Protein is expressed from E.coli with N-terminal 6xHis-KSI-tagged. It contains 1-38aa. [Accession | P28221].
Uniprot No.P28221
Gene NamesHTR1D
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-38aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-KSI-tagged
Molecular weight19.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Detected in brain neocortex and caudate nucleus (at protein level)

Product Specifications

Recombinant Human 5-hydroxytryptamine receptor 1D (HTR1D), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-38aa, with N-terminal 6xHis-KSI-tagged tag, molecular weight 19.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968). May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968). May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Detected in brain neocortex and caudate nucleus (at protein level)

Subunit

Homodimer. Heterodimer with HTR1B

Gene: HTR1D  |  Organism: Homo sapiens  |  Synonyms: Serotonin 1D alpha receptor; Serotonin receptor 1D
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top