Recombinant Human 78 kDa glucose-regulated protein (HSPA5), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 76.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human 78 kDa glucose-regulated protein (HSPA5)

Recombinant Human 78 kDa glucose-regulated protein (HSPA5) — (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion … Purity >90%.

SKU: BCRECP-000865 Category:
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Product Specifications

Product SkuBCRECP-000865
Product DescriptionRecombinant Human 78 kDa glucose-regulated protein (HSPA5) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 19-654aa. [Accession | P11021].
Uniprot No.P11021
Gene NamesHSPA5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region19-654aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight76.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

(Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi. Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression.

Biological Context

Subcellular Location: Endoplasmic reticulum lumen; Melanosome; Cytoplasm; Cell surface
Disease Association: [Autoantigen in rheumatoid arthritis]

Product Specifications

Recombinant Human 78 kDa glucose-regulated protein (HSPA5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 19-654aa, with N-terminal 6xHis-tagged tag, molecular weight 76.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760)

Subcellular Location

Endoplasmic reticulum lumen; Melanosome; Cytoplasm; Cell surface

Disease Association

[Autoantigen in rheumatoid arthritis]

Subunit

(Microbial infection) Interacts with Zika virus envelope protein E and non-structural protein 1 in a chaperone-client manner

Gene: HSPA5  |  Organism: Homo sapiens  |  Synonyms: 78 kDa glucose-regulated protein; Binding-immunoglobulin protein; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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