Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Biological Context
Subcellular Location: Cytoplasm, cytoskeleton
Disease Association: Cardiomyopathy, dilated, 1R (CMD1R) : A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. [The disease is caused by variants affecting the gene represented in this entry] | Cardiomyopathy, familial hypertrophic, 11 (CMH11) : A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. [The disease is caused by variants affecting the gene represented in this entry] | Atrial septal defect 5 (ASD5) : A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Actin, alpha cardiac muscle 1 (ACTC1), partial is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 3-377aa, with C-terminal 6xHis-tagged tag, molecular weight 47.4kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
