Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 45.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP)

Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) — Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Purity >90%.

SKU: BCRECP-000125 Category:
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Product Specifications

Product SkuBCRECP-000125
Product DescriptionRecombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-163aa. [Accession | Q9Y2Y0].
Uniprot No.Q9Y2Y0
Gene NamesARL2BP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-163aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight45.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.

Biological Context

Subcellular Location: Cytoplasm; Mitochondrion intermembrane space; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, cilium basal body
Tissue Specificity: Expressed in retina pigment epithelial cells (at protein level). Widely expressed
Disease Association: Retinitis pigmentosa 82 with or without situs inversus (RP82) : An autosomal recessive disorder characterized by variable association of retinitis pigmentosa with situs inversus. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Situs inversus is a congenital abnormality in which organs in the thorax and the abdomen are opposite to their normal positions due to lateral transposition. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-163aa, with N-terminal GST-tagged tag, molecular weight 45.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2

Subcellular Location

Cytoplasm; Mitochondrion intermembrane space; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, cilium basal body

Disease Association

Retinitis pigmentosa 82 with or without situs inversus (RP82) : An autosomal recessive disorder characterized by variable association of retinitis pigmentosa with situs inversus. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Situs inversus is a congenital abnormality in which organs in the thorax and the abdomen are opposite to their normal positions due to lateral transposition. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in retina pigment epithelial cells (at protein level). Widely expressed

Subunit

Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Interacts with GTP-bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to SLC25A4. Interaction with ARL2 may be required for targeting to cilia basal body. Interacts with STAT3; interaction is enhanced with ARL2

Gene: ARL2BP  |  Organism: Homo sapiens  |  Synonyms: Binder of ARF2 protein 1
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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