Recombinant Human Alpha-galactosidase A (GLA), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 49.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Alpha-galactosidase A (GLA)

Recombinant Human Alpha-galactosidase A (GLA) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000753 Category:
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Product Specifications

Product SkuBCRECP-000753
Product DescriptionRecombinant Human Alpha-galactosidase A (GLA) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 32-429aa. [Accession | P06280].
Uniprot No.P06280
Gene NamesGLA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region32-429aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight49.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.

Biological Context

Subcellular Location: Lysosome
Disease Association: Fabry disease (FABRYD) : An X-linked inborn error of glycosphingolipid catabolism due to lysosomal alpha-galactosidase A deficiency, leading to systemic accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids. Clinical features include angiokeratomas over the lower trunk, progressive renal failure, cardiac disease, cerebrovascular disease, small-fiber peripheral neuropathy, febrile episodes, and burning pain in the extremities. Disease onset is usually in childhood or adolescence. Death results from renal failure, cardiac or cerebrovascular disease. Heterozygous females may exhibit the disorder in an attenuated form. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Alpha-galactosidase A (GLA) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 32-429aa, with N-terminal 6xHis-tagged tag, molecular weight 49.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome

Subcellular Location

Lysosome

Disease Association

Fabry disease (FABRYD) : An X-linked inborn error of glycosphingolipid catabolism due to lysosomal alpha-galactosidase A deficiency, leading to systemic accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids. Clinical features include angiokeratomas over the lower trunk, progressive renal failure, cardiac disease, cerebrovascular disease, small-fiber peripheral neuropathy, febrile episodes, and burning pain in the extremities. Disease onset is usually in childhood or adolescence. Death results from renal failure, cardiac or cerebrovascular disease. Heterozygous females may exhibit the disorder in an attenuated form. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer

Gene: GLA  |  Organism: Homo sapiens  |  Synonyms: Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Galactosylgalactosylglucosylceramidase GLA; Melibiase
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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