Recombinant Human Apolipoprotein L domain-containing protein 1 (APOLD1) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 33.4kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Apolipoprotein L domain-containing protein 1 (APOLD1) Protein

Recombinant Human Apolipoprotein L domain-containing protein 1 (APOLD1) Protein — Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton. Purity >85%.

SKU: BCRECP-00089TM Category:
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Product Specifications

Uniprot No.Q96LR9
Gene NamesAPOLD1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-279aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight33.4kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton. It also plays a role in the modulation of secretory autophagy. May affect blood-brain barrier permeability.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Cell junction; Cytoplasmic vesicle, secretory vesicle
Tissue Specificity: Expressed in neonatal dermal microvascular endothelial cells
Disease Association: Bleeding disorder, vascular-type (BDVAS) : An autosomal dominant disorder characterized by increased bleeding tendency, without platelet dysfunction. Affected individuals experience spontaneous episodic bleeding, usually beginning in childhood. Clinical manifestations include epistaxis, oral cavity bleeding, menorrhagia, and excessive bleeding during surgery or childbirth. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Apolipoprotein L domain-containing protein 1 (APOLD1) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-279aa, with N-terminal 10xHis-tagged tag, molecular weight 33.4kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton (PubMed:35638551). It also plays a role in the modulation of secretory autophagy (PubMed:35638551). May affect blood-brain barrier permeability

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cell junction; Cytoplasmic vesicle, secretory vesicle

Disease Association

Bleeding disorder, vascular-type (BDVAS) : An autosomal dominant disorder characterized by increased bleeding tendency, without platelet dysfunction. Affected individuals experience spontaneous episodic bleeding, usually beginning in childhood. Clinical manifestations include epistaxis, oral cavity bleeding, menorrhagia, and excessive bleeding during surgery or childbirth. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in neonatal dermal microvascular endothelial cells

Gene: APOLD1  |  Organism: Homo sapiens  |  Synonyms: Vascular early response gene protein

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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