Recombinant Human AT-rich interactive domain-containing protein 4B (ARID4B), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 32.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human AT-rich interactive domain-containing protein 4B (ARID4B), partial

Recombinant Human AT-rich interactive domain-containing protein 4B (ARID4B), partial — Acts as a transcriptional repressor. Purity >85%.

SKU: BCRECP-000124 Category:
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Product Specifications

Product SkuBCRECP-000124
Product DescriptionRecombinant Human AT-rich interactive domain-containing protein 4B (ARID4B) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 167-415aa. [Accession | Q4LE39].
Uniprot No.Q4LE39
Gene NamesARID4B
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region167-415aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A.

Biological Context

Subcellular Location: Nucleus; Cytoplasm
Tissue Specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary

Product Specifications

Recombinant Human AT-rich interactive domain-containing protein 4B (ARID4B), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 167-415aa, with N-terminal 6xHis-tagged tag, molecular weight 32.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity)

Subcellular Location

Nucleus; Cytoplasm

Tissue Specificity

Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary

Subunit

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404). Interacts with ARID4A (PubMed:17043311). Interacts with AR (By similarity)

Gene: ARID4B  |  Organism: Homo sapiens  |  Synonyms: 180 kDa Sin3-associated polypeptide; Breast cancer-associated antigen BRCAA1; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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