Recombinant Human ATP-binding cassette sub-family D member 2 (ABCD2) Protein

Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transported in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416)

Subcellular Location

Peroxisome membrane (Multi-pass membrane protein)

Tissue Specificity

Predominantly expressed in brain and heart

Subunit

Homodimers (By similarity). Homotetramers (By similarity). The minimal functional unit is a homodimer but the major oligomeric form in peroxisomal membrane is a homotetramer (By similarity). Forms heterodimers with ABCD1 (PubMed:17609205). Forms heterodimers with ABCD3 (PubMed:10551832). In addition to tetramers, some larger molecular assemblies are also found but represented only a minor fraction (By similarity). Interacts with PEX19; facilitates ABCD2 insertion into the peroxisome membrane (PubMed:10704444, PubMed:10777694)

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