Recombinant Human Atrial natriuretic peptide receptor 3 (NPR3), partial

Function

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Boudin-Mortier syndrome (BOMOS) : An autosomal recessive disorder characterized by tall stature, long digits, and extra epiphyses in the hands and feet. In addition, some patients show joint hypermobility and dilation of the aortic root. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer; disulfide-linked (PubMed:11533490). Dimers can also be formed through the C-terminal cysteine of isoform 2 (PubMed:11533490). Interacts with OSTN (By similarity)

• Lowe D.G. et al. cDNA sequence of the human atrial natriuretic peptide clearance receptor. — Nucleic Acids Res. (1990)
• Porter J.G. et al. Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA. — Biochem. Biophys. Res. Commun. (1990)
• Rae J.L. et al. Human lens epithelial mRNA for atrial natriuretic peptide clearance receptor. (NOV-)
• Ota T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. — Nat. Genet. (2004)
• Schmutz J. et al. The DNA sequence and comparative analysis of human chromosome 5. — Nature (2004)
• Mural R.J. et al. PubMed: CI-5GBDQ6B103N1E (JUL-)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Stults J.T. et al. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. — Biochemistry (1994)