Recombinant Human Atypical chemokine receptor 3 (ACKR3) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 6xHis-SUMO-tagged, 57.5kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Atypical chemokine receptor 3 (ACKR3) Protein

Recombinant Human Atypical chemokine receptor 3 (ACKR3) Protein — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >90%.

SKU: BCRECP-00618TM Categories: ,
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Product Specifications

Uniprot No.P25106
Gene NamesACKR3
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-362aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight57.5kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

(Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Early endosome; Recycling endosome
Tissue Specificity: Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level)
Disease Association: Oculomotor-abducens synkinesis (OCABSN) : An autosomal recessive disorder characterized by ptosis and elevation of the eyelid on ipsilateral abduction. OCABSN features are consistent with abnormal innervation of the levator palpebrae superioris muscle, which raises the eyelid, and the lateral rectus muscle, which controls lateral eye movement. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Atypical chemokine receptor 3 (ACKR3) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-362aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 57.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates

Subcellular Location

Cell membrane (Multi-pass membrane protein); Early endosome; Recycling endosome

Disease Association

Oculomotor-abducens synkinesis (OCABSN) : An autosomal recessive disorder characterized by ptosis and elevation of the eyelid on ipsilateral abduction. OCABSN features are consistent with abnormal innervation of the levator palpebrae superioris muscle, which raises the eyelid, and the lateral rectus muscle, which controls lateral eye movement. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level)

Subunit

(Microbial infection) Interacts with Kaposi virus protein vCCL2

Gene: ACKR3  |  Organism: Homo sapiens  |  Synonyms: C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G protein-coupled receptor 159; G protein-coupled receptor RDC1 homolog
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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