Recombinant Human Axin-2 (AXIN2), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 18.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Axin-2 (AXIN2), partial

Recombinant Human Axin-2 (AXIN2), partial — Inhibitor of the Wnt signaling pathway. Purity >90%.

SKU: BCRECP-000143 Category:
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Product Specifications

Product SkuBCRECP-000143
Product DescriptionRecombinant Human Axin-2 (AXIN2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 745-843aa. [Accession | Q9Y2T1].
Uniprot No.Q9Y2T1
Gene NamesAXIN2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region745-843aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight18.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Expressed in brain and lymphoblast
Disease Association: Colorectal cancer (CRC) : A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. [The gene represented in this entry is involved in disease pathogenesis] | Oligodontia-colorectal cancer syndrome (ODCRCS) : Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Axin-2 (AXIN2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 745-843aa, with C-terminal 6xHis-tagged tag, molecular weight 18.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B

Subcellular Location

Cytoplasm

Disease Association

Colorectal cancer (CRC) : A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. [The gene represented in this entry is involved in disease pathogenesis] | Oligodontia-colorectal cancer syndrome (ODCRCS) : Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in brain and lymphoblast

Subunit

Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6. Interacts with SIAH1 (PubMed:28546513). Interacts with SIAH2 (PubMed:28546513)

Gene: AXIN2  |  Organism: Homo sapiens  |  Synonyms: Axin-like protein; Axis inhibition protein 2; Conductin
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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