Recombinant Human Axin-2 (AXIN2), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 18.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Axin-2 (AXIN2), partial

Recombinant Human Axin-2 (AXIN2), partial — Inhibitor of the Wnt signaling pathway. Purity >90%.

SKU: BCRECP-000143 Category:
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Product Specifications

Product SkuBCRECP-000143
Product DescriptionRecombinant Human Axin-2 (AXIN2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 745-843aa. [Accession | Q9Y2T1].
Uniprot No.Q9Y2T1
Gene NamesAXIN2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region745-843aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight18.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Expressed in brain and lymphoblast
Disease Association: Colorectal cancer (CRC) : A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. [The gene represented in this entry is involved in disease pathogenesis] | Oligodontia-colorectal cancer syndrome (ODCRCS) : Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Axin-2 (AXIN2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 745-843aa, with C-terminal 6xHis-tagged tag, molecular weight 18.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B

Subcellular Location

Cytoplasm

Disease Association

Colorectal cancer (CRC) : A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. [The gene represented in this entry is involved in disease pathogenesis] | Oligodontia-colorectal cancer syndrome (ODCRCS) : Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in brain and lymphoblast

Subunit

Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6. Interacts with SIAH1 (PubMed:28546513). Interacts with SIAH2 (PubMed:28546513)

Gene: AXIN2  |  Organism: Homo sapiens  |  Synonyms: Axin-like protein; Axis inhibition protein 2; Conductin
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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