Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 25.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L)

Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) — Induces apoptosis. Purity >90%.

SKU: BCRECP-000170 Categories: ,
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Product Specifications

Product SkuBCRECP-000170
Product DescriptionRecombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-219aa. [Accession | O60238].
Uniprot No.O60238
Gene NamesBNIP3L
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-219aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight25.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis.

Biological Context

Subcellular Location: Nucleus envelope; Endoplasmic reticulum; Mitochondrion outer membrane; Membrane (Single-pass membrane protein)

Product Specifications

Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-219aa, with N-terminal 6xHis-tagged tag, molecular weight 25.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor

Subcellular Location

Nucleus envelope; Endoplasmic reticulum; Mitochondrion outer membrane; Membrane (Single-pass membrane protein)

Subunit

(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus protein VIRF-1

Gene: BNIP3L  |  Organism: Homo sapiens  |  Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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