Recombinant Human Beta-defensin 1 protein (DEFB1) (Active), Homo sapiens (Human), E.Coli, Tag-Free, 5.1 kDa, purity >>98% as determined by SDS-PAGE.

Recombinant Human Beta-defensin 1 protein (DEFB1) (Active)

Recombinant Human Beta-defensin 1 protein (DEFB1) (Active) — Has bactericidal activity. Purity >98%.

SKU: BCACP-000887 Category:
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Product SKUBCACP-000887
Product DescriptionRecombinant Human Beta-defensin 1 protein (DEFB1) protein is expressed from E.Coli with Tag-Free. It contains 22-68aa. [Accession | P60022].
Uniprot No.P60022
Gene NamesDEFB1
Purity>98% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region22-68aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight5.1 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesBD 1; BD-1; BD1; beta 1; Beta defensin 1; Beta-defensin 1; DEFB 1; DEFB1; DEFB1_HUMAN; DEFB101; Defensin; Defensin beta 1; Defensin beta 1 preproprotein; HBD 1; hBD-1; HBD1; MGC51822

Function

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.

Biological Context

Subcellular Location: Secreted; Membrane
Tissue Specificity: Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level)

Product Specifications

Recombinant Human Beta-defensin 1 protein (DEFB1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 22-68aa, with Tag-Free tag, molecular weight 5.1 kDa, purity >98% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636)

Subcellular Location

Secreted; Membrane

Tissue Specificity

Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level)

Subunit

Monomer (PubMed:23938203). Homodimer (PubMed:23938203)

Gene: DEFB1  |  Organism: Homo sapiens  |  Synonyms: Defensin, beta 1
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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