Function
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Biological Context
Subcellular Location: Apical cell membrane (Multi-pass membrane protein); Recycling endosome membrane (Multi-pass membrane protein); Endosome; Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ
Disease Association: Cholestasis, progressive familial intrahepatic, 2 (PFIC2) : A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC2 inheritance is autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry] | Cholestasis, benign recurrent intrahepatic, 2 (BRIC2) : A disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Bile salt export pump (ABCB11), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1033-1321aa, with N-terminal 6xHis-tagged tag, molecular weight 35.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
