Recombinant Human BRCA1-associated protein (BRAP), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 33.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human BRCA1-associated protein (BRAP), partial

Recombinant Human BRCA1-associated protein (BRAP), partial — Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Purity >90%.

SKU: BCRECP-000175 Category:
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Product Specifications

Product SkuBCRECP-000175
Product DescriptionRecombinant Human BRCA1-associated protein (BRAP) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 294-346aa. [Accession | J3KNN7].
Uniprot No.J3KNN7
Gene NamesBRAP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region294-346aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight33.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Biological Context

Subcellular Location: Cytoplasm
Pathway: Protein modification; protein ubiquitination

Product Specifications

Recombinant Human BRCA1-associated protein (BRAP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 294-346aa, with N-terminal GST-tagged tag, molecular weight 33.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport

Subcellular Location

Cytoplasm

Pathway

Protein modification; protein ubiquitination

Gene: BRAP  |  Organism: Homo sapiens  |  Synonyms: BRAP2; Impedes mitogenic signal propagation; RING-type E3 ubiquitin transferase BRAP2
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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