Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1), Homo sapiens (Human), E.coli, N-terminal 6xHis-Trx-tagged, 25.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) — Potent and specific inhibitor of CaM-kinase II (CAMK2). Purity >85%.

SKU: BCRECP-000229 Categories: , ,
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Product Specifications

Product SkuBCRECP-000229
Product DescriptionRecombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) Protein is expressed from E.coli with N-terminal 6xHis-Trx-tagged. It contains 1-78aa. [Accession | Q7Z7J9].
Uniprot No.Q7Z7J9
Gene NamesCAMK2N1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-78aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-Trx-tagged
Molecular weight25.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Potent and specific inhibitor of CaM-kinase II (CAMK2). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear. Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass.

Biological Context

Subcellular Location: Synapse; Cell projection, dendrite; Postsynaptic density

Product Specifications

Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-78aa, with N-terminal 6xHis-Trx-tagged tag, molecular weight 25.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity)

Subcellular Location

Synapse; Cell projection, dendrite; Postsynaptic density

Subunit

Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+) (By similarity)

Gene: CAMK2N1  |  Organism: Homo sapiens  |  Synonyms: CaMKII inhibitory protein alpha

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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