Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1), Homo sapiens (Human), E.coli, N-terminal 6xHis-Trx-tagged, 25.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) — Potent and specific inhibitor of CaM-kinase II (CAMK2). Purity >85%.

SKU: BCRECP-000229 Categories: , ,
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Product Specifications

Product SkuBCRECP-000229
Product DescriptionRecombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) Protein is expressed from E.coli with N-terminal 6xHis-Trx-tagged. It contains 1-78aa. [Accession | Q7Z7J9].
Uniprot No.Q7Z7J9
Gene NamesCAMK2N1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-78aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-Trx-tagged
Molecular weight25.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Potent and specific inhibitor of CaM-kinase II (CAMK2). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear. Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass.

Biological Context

Subcellular Location: Synapse; Cell projection, dendrite; Postsynaptic density

Product Specifications

Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-78aa, with N-terminal 6xHis-Trx-tagged tag, molecular weight 25.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity)

Subcellular Location

Synapse; Cell projection, dendrite; Postsynaptic density

Subunit

Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+) (By similarity)

Gene: CAMK2N1  |  Organism: Homo sapiens  |  Synonyms: CaMKII inhibitory protein alpha

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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