Recombinant Human Calpain small subunit 1 (CAPNS1), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 44.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Calpain small subunit 1 (CAPNS1)

Recombinant Human Calpain small subunit 1 (CAPNS1) — Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Purity >90%.

SKU: BCRECP-000233 Category:
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Product Specifications

Product SkuBCRECP-000233
Product DescriptionRecombinant Human Calpain small subunit 1 (CAPNS1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-268aa. [Accession | P04632].
Uniprot No.P04632
Gene NamesCAPNS1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-268aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight44.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development.

Biological Context

Subcellular Location: Cytoplasm; Cell membrane
Disease Association: Pulmonary hypertension, primary, 6 (PPH6) : A form of primary pulmonary hypertension, a disease defined by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. Primary pulmonary hypertension exhibits incomplete penetrance, sex bias and variable age of onset, both within and between families. PPH6 is an autosomal recessive form. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Calpain small subunit 1 (CAPNS1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-268aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 44.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)

Subcellular Location

Cytoplasm; Cell membrane

Disease Association

Pulmonary hypertension, primary, 6 (PPH6) : A form of primary pulmonary hypertension, a disease defined by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. Primary pulmonary hypertension exhibits incomplete penetrance, sex bias and variable age of onset, both within and between families. PPH6 is an autosomal recessive form. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity)

Gene: CAPNS1  |  Organism: Homo sapiens  |  Synonyms: Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; Calpain regulatory subunit

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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