Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Biological Context
Subcellular Location: Endoplasmic reticulum lumen
Tissue Specificity: Expressed in liver, colon and small intestine
Product Specifications
Recombinant Human Carboxylesterase 3 (CES3) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 27-571aa, with C-terminal 6xHis-tagged tag, molecular weight 61.1kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications. Explore more Enzyme proteins →
