Recombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 69.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L)

Recombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L) — Has 3′-5′ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Purity >85%.

SKU: BCRECP-000395 Category:
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Product Specifications

Product SkuBCRECP-000395
Product DescriptionRecombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 1-555aa. [Accession | Q96LI5].
Uniprot No.Q96LI5
Gene NamesCNOT6L
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-555aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight69.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus

Product Specifications

Recombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-555aa, with N-terminal 10xHis-tagged tag, molecular weight 69.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence

Subcellular Location

Cytoplasm; Nucleus

Tissue Specificity

Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus

Subunit

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:17452450, PubMed:18377426, PubMed:19558367). Interacts with CNOT1, CNOT3, CNOT7, CNOT8 and CNOT9 (PubMed:17452450). Interacts with TOB1 (PubMed:18377426). Interacts with NANOS2 (By similarity). Interacts with ZFP36 (By similarity). Interacts with ZFP36L2 (PubMed:34611029). Interacts with RBM46 (By similarity)

Gene: CNOT6L  |  Organism: Homo sapiens  |  Synonyms: Carbon catabolite repressor protein 4 homolog B
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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