Recombinant Human CD44 antigen (CD44), partial,Biotinylated (Active), Homo sapiens (Human), Mammalian cell, C-terminal mFc-Avi-tagged, 51.0 kDa, purity >90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
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Recombinant Human CD44 antigen (CD44), partial,Biotinylated (Active)

Recombinant Human CD44 antigen (CD44), partial,Biotinylated (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >90%.

SKU: BCACP-000100 Categories: , , ,
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Product SKUBCACP-000100
Product DescriptionRecombinant Human CD44 antigen (CD44), Biotinylated protein is expressed from Mammalian cell with C-terminal mFc-Avi-tagged. It contains 21-220aa. [Accession | P16070].
Uniprot No.P16070
Gene NamesCD44
PurityGreater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region21-220aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal mFc-Avi-tagged
Molecular weight51.0 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized MUC16 at 10 μg/ml can bind MSLN, the EC50 is 460.7-662.2 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(CDw44)(Epican)(Extracellular matrix receptor III)(ECMR-III)(GP90 lymphocyte homing/adhesion receptor)(HUTCH-I)(Heparan sulfate proteoglycan)(Hermes antigen)(Hyaluronate receptor)(Phagocytic glycoprotein 1)(PGP-1)(Phagocytic glycoprotein I)(PGP-I)(LHR)(MDU2)(MDU3)(MIC4)

Function

(Microbial infection) Promotes foot-and-mouth disease virus internalization via macropinocytosis.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell projection, microvillus; Secreted
Tissue Specificity: Detected in fibroblasts and urine (at protein level). Detected in placenta (at protein level). Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells

Product Specifications

Recombinant Human CD44 antigen (CD44), partial,Biotinylated (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 21-220aa, with C-terminal mFc-Avi-tagged tag, molecular weight 51.0 kDa, purity Greater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized MUC16 at 10 μg/ml can bind MSLN, the EC50 is 460.7-662.2 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Promotes foot-and-mouth disease virus internalization via macropinocytosis

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell projection, microvillus; Secreted

Tissue Specificity

Detected in fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells

Subunit

(Microbial infection) Interacts with foot-and-mouth disease virus protein VP3; this interaction allows FMDV entry into host cell via macropinocytosis

Gene: CD44  |  Organism: Homo sapiens  |  Synonyms: CDw44; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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