Recombinant Human Cell surface hyaluronidase CEMIP2 (CEMIP2), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 21.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Cell surface hyaluronidase CEMIP2 (CEMIP2), partial

Recombinant Human Cell surface hyaluronidase CEMIP2 (CEMIP2), partial — Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments. Purity >85%.

SKU: BCRECP-000353 Category:
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Product Specifications

Product SkuBCRECP-000353
Product DescriptionRecombinant Human Cell surface hyaluronidase CEMIP2 (CEMIP2) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 104-250aa. [Accession | Q9UHN6].
Uniprot No.Q9UHN6
Gene NamesCEMIP2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region104-250aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight21.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments. Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites.

Biological Context

Subcellular Location: Cell membrane (Single-pass type II membrane protein)
Tissue Specificity: Widely expressed

Product Specifications

Recombinant Human Cell surface hyaluronidase CEMIP2 (CEMIP2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 104-250aa, with N-terminal 10xHis-tagged tag, molecular weight 21.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments (PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity)

Subcellular Location

Cell membrane (Single-pass type II membrane protein)

Tissue Specificity

Widely expressed

Gene: CEMIP2  |  Organism: Homo sapiens  |  Synonyms: Cell migration-inducing hyaluronidase 2; Transmembrane protein 2
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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