Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 (CLN5), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 43.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 (CLN5) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000385 Category:
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Product Specifications

Product SkuBCRECP-000385
Product DescriptionRecombinant Human Ceroid-lipofuscinosis neuronal protein 5 (CLN5) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 47-358aa. [Accession | O75503].
Uniprot No.O75503
Gene NamesCLN5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region47-358aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight43.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Ubiquitous
Disease Association: Ceroid lipofuscinosis, neuronal, 5 (CLN5) : A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 5 comprise mixed combinations of granular, curvilinear, and fingerprint profiles. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 (CLN5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 47-358aa, with C-terminal 6xHis-tagged tag, molecular weight 43.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation

Subcellular Location

Membrane (Single-pass type II membrane protein)

Disease Association

Ceroid lipofuscinosis, neuronal, 5 (CLN5) : A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 5 comprise mixed combinations of granular, curvilinear, and fingerprint profiles. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Ubiquitous

Subunit

Multimer (PubMed:37708259). Interacts with SORT1, RAB5A and RAB7A (PubMed:22431521). Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B (By similarity)

Gene: CLN5  |  Organism: Homo sapiens  |  Synonyms: Ceroid-lipofuscinosis neuronal protein 5; Palmitoyl protein thioesterase CLN5; S-depalmitoylase CLN5
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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