Recombinant Human Chromogranin-A (CHGA), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 50.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Chromogranin-A (CHGA)

Recombinant Human Chromogranin-A (CHGA) — Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. Purity >90%.

SKU: BCRECP-000360 Category:
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Product Specifications

Product SkuBCRECP-000360
Product DescriptionRecombinant Human Chromogranin-A (CHGA) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 19-457aa. [Accession | P10645].
Uniprot No.P10645
Gene NamesCHGA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region19-457aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight50.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Biological Context

Subcellular Location: Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle; Secreted
Tissue Specificity: Found in the brain

Product Specifications

Recombinant Human Chromogranin-A (CHGA) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 19-457aa, with N-terminal 6xHis-tagged tag, molecular weight 50.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation

Subcellular Location

Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle; Secreted

Tissue Specificity

Found in the brain

Subunit

Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (PubMed:25326458). Interacts with SCG3 (By similarity). Interacts with ITPR1 in the secretory granules (By similarity)

Gene: CHGA  |  Organism: Homo sapiens  |  Synonyms: Pituitary secretory protein I
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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