Recombinant Human Coagulation factor VII (F7), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 33.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Coagulation factor VII (F7), partial

Recombinant Human Coagulation factor VII (F7), partial — Initiates the extrinsic pathway of blood coagulation. Purity >90%.

SKU: BCRECP-000621 Category:
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Product Specifications

Product SkuBCRECP-000621
Product DescriptionRecombinant Human Coagulation factor VII (F7) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 61-212aa. [Accession | P08709].
Uniprot No.P08709
Gene NamesF7
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region61-212aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight33.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Plasma
Disease Association: Factor VII deficiency (FA7D) : A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Coagulation factor VII (F7), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 61-212aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 33.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)

Subcellular Location

Secreted

Disease Association

Factor VII deficiency (FA7D) : A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Plasma

Subunit

Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392)

Gene: F7  |  Organism: Homo sapiens  |  Synonyms: Proconvertin; Serum prothrombin conversion accelerator

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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