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Recombinant Human Coagulation factor XIII A chain (F13A1)

Recombinant Human Coagulation factor XIII A chain (F13A1) — Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibr… Purity >90%.

SKU: BCRECP-000613 Category:
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Product Specifications

Product SkuBCRECP-000613
Product DescriptionRecombinant Human Coagulation factor XIII A chain (F13A1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 39-732aa. [Accession | P00488].
Uniprot No.P00488
Gene NamesF13A1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region39-732aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight81.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Biological Context

Subcellular Location: Cytoplasm; Secreted
Disease Association: Factor XIII subunit A deficiency (FA13AD) : An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Coagulation factor XIII A chain (F13A1) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 39-732aa, with N-terminal 6xHis-tagged tag, molecular weight 81.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin

Subcellular Location

Cytoplasm; Secreted

Disease Association

Factor XIII subunit A deficiency (FA13AD) : An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Tetramer of two A chains (F13A1) and two B (F13B) chains

Gene: F13A1  |  Organism: Homo sapiens  |  Synonyms: Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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