Recombinant Human Cobalamin binding intrinsic factor (CBLIF)

Recombinant Human Cobalamin binding intrinsic factor (CBLIF) — Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. Purity >90%.

SKU: BCRECP-000241 Category:

Product Specifications

Product SkuBCRECP-000241
Product DescriptionRecombinant Human Cobalamin binding intrinsic factor (CBLIF) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 19-417aa. [Accession | P27352].
Uniprot No.P27352
Gene NamesCBLIF
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region19-417aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight45.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Gastric mucosa
Disease Association: Hereditary intrinsic factor deficiency (IFD) : Autosomal recessive disorder characterized by megaloblastic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cobalamin binding intrinsic factor (CBLIF) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 19-417aa, with N-terminal 6xHis-tagged tag, molecular weight 45.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis

Subcellular Location

Secreted

Disease Association

Hereditary intrinsic factor deficiency (IFD) : Autosomal recessive disorder characterized by megaloblastic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Gastric mucosa

Subunit

Interacts with CUBN (via CUB domains)

Gene: CBLIF  |  Organism: Homo sapiens  |  Synonyms: Gastric intrinsic factor; Intrinsic factor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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