Recombinant Human Cold-inducible RNA-binding protein (CIRBP), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 50.2kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Cold-inducible RNA-binding protein (CIRBP)

Recombinant Human Cold-inducible RNA-binding protein (CIRBP) — Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Purity >95%.

SKU: BCRECP-000370 Category:
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Product Specifications

Product SkuBCRECP-000370
Product DescriptionRecombinant Human Cold-inducible RNA-binding protein (CIRBP) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-172aa. [Accession | Q14011].
Uniprot No.Q14011
Gene NamesCIRBP
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-172aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight50.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation.

Biological Context

Subcellular Location: Nucleus, nucleoplasm; Cytoplasm
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human Cold-inducible RNA-binding protein (CIRBP) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-172aa, with N-terminal GST-tagged tag, molecular weight 50.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed

Subcellular Location

Nucleus, nucleoplasm; Cytoplasm

Tissue Specificity

Ubiquitous

Subunit

Interacts with EIF4G1. Associates with ribosomes

Gene: CIRBP  |  Organism: Homo sapiens  |  Synonyms: A18 hnRNP; Glycine-rich RNA-binding protein CIRP
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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