Function
Acts as a chemoattractant for neutrophils in chronic inflammation.
Biological Context
Subcellular Location: Secreted
Tissue Specificity: Produced in adipocytes and released into the plasma during both the fasting and postprandial periods
Disease Association: Complement component 3 deficiency (C3D) : A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. [The disease is caused by variants affecting the gene represented in this entry] | Macular degeneration, age-related, 9 (ARMD9) : A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [Disease susceptibility is associated with variants affecting the gene represented in this entry] | Hemolytic uremic syndrome, atypical, 5 (AHUS5) : An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. [Disease susceptibility is associated with variants affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype] | [Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage]
Product Specifications
Recombinant Human Complement C3 (C3), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 26-225aa, with N-terminal 6xHis-tagged tag, molecular weight 26.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
