Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 Protein, HEK293 Cells, N-6His, 16.3 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 Protein

Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 Protein — Major connective tissue mitoattractant secreted by vascular endothelial cells. Purity >95%.

SKU: BCRETP-000049 Categories: ,
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Product Specifications

Product SkuBCRETP-000049
Product DescriptionRecombinant Human Connective Tissue Growth Factor/CTGF/CCN2 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains 27-180aa. [Accession | P29279].
Uniprot No.P29279
SynonymsConnective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemHEK293 Cells
Expression Region27-180aa
Tag InfoN-6His
Molecular weight16.3 kDa
EndotoxinLess than 1.0 EU/μg as determined by LAL method.

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix; Secreted
Tissue Specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested
Disease Association: Kyphomelic dysplasia (KMD) : An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears. [The disease may be caused by variants affecting the gene represented in this entry] | Spondyloepimetaphyseal dysplasia, Li-Shao-Li type (SEMDLSL) : A form of spondyloepimetaphyseal dysplasia, a clinically and genetically heterogeneous group of skeletal disorders marked by vertebral, epiphyseal, and metaphyseal abnormalities. SEMDLSL is an autosomal dominant form characterized by childhood onset of defective skeletal development. Affected individuals exhibit disproportionate short stature, short lower limbs, limited joint flexion, premature osteoarthritis-like changes in weight-bearing joints, and low bone mass. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 Protein is a recombinant protein, expressed in HEK293 Cells, covering amino acids 27-180aa, with N-6His tag, molecular weight 16.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis

Subcellular Location

Secreted, extracellular space, extracellular matrix; Secreted

Disease Association

Kyphomelic dysplasia (KMD) : An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears. [The disease may be caused by variants affecting the gene represented in this entry] | Spondyloepimetaphyseal dysplasia, Li-Shao-Li type (SEMDLSL) : A form of spondyloepimetaphyseal dysplasia, a clinically and genetically heterogeneous group of skeletal disorders marked by vertebral, epiphyseal, and metaphyseal abnormalities. SEMDLSL is an autosomal dominant form characterized by childhood onset of defective skeletal development. Affected individuals exhibit disproportionate short stature, short lower limbs, limited joint flexion, premature osteoarthritis-like changes in weight-bearing joints, and low bone mass. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested

Subunit

Monomer (PubMed:1654338). Interacts with TSKU (PubMed:30232710)

Gene: CCN2  |  Organism: Homo sapiens  |  Synonyms: Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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