Recombinant Human Cytochrome P450 2A6 (CYP2A6), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 60.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Cytochrome P450 2A6 (CYP2A6), partial

Recombinant Human Cytochrome P450 2A6 (CYP2A6), partial — Exhibits a high coumarin 7-hydroxylase activity. Purity >85%.

SKU: BCRECP-000469 Category:
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Product Specifications

Product SkuBCRECP-000469
Product DescriptionRecombinant Human Cytochrome P450 2A6 (CYP2A6) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 29-494aa. [Accession | P11509].
Uniprot No.P11509
Gene NamesCYP2A6
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-494aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight60.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur. Competent in the metabolic activation of aflatoxin B1.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Peripheral membrane protein); Microsome membrane (Peripheral membrane protein)
Tissue Specificity: Liver

Product Specifications

Recombinant Human Cytochrome P450 2A6 (CYP2A6), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 29-494aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 60.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity

Subcellular Location

Endoplasmic reticulum membrane (Peripheral membrane protein); Microsome membrane (Peripheral membrane protein)

Tissue Specificity

Liver

Gene: CYP2A6  |  Organism: Homo sapiens  |  Synonyms: 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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