Recombinant Human D (2) dopamine receptor (DRD2), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 25.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human D (2) dopamine receptor (DRD2), partial

Recombinant Human D (2) dopamine receptor (DRD2), partial — Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Purity >85%.

SKU: BCRECP-000535 Category:
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Product Specifications

Product SkuBCRECP-000535
Product DescriptionRecombinant Human D (2) dopamine receptor (DRD2) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 214-373aa. [Accession | P14416].
Uniprot No.P14416
Gene NamesDRD2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region214-373aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight25.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasG-protein coupled receptor, Receptor, Transducer

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Golgi apparatus membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in the anterior pituitary gland

Product Specifications

Recombinant Human D (2) dopamine receptor (DRD2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 214-373aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 25.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528, PubMed:39103320). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Golgi apparatus membrane (Multi-pass membrane protein)

Tissue Specificity

Expressed in the anterior pituitary gland

Subunit

Interacts with GNAO1, GNB1 and GNG2; interaction with a heterotrimeric G protein complex is essential for receptor activity (PubMed:39103320). Interacts with GNAI2 isoform sGi2; the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964). Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CADPS and CADPS2 (PubMed:15857609). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (PubMed:21645528). Interacts with DRD1 (By similarity). Interacts with KCNA2 (By similarity)

Gene: DRD2  |  Organism: Homo sapiens  |  Synonyms: Dopamine D2 receptor
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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