Recombinant Human Desmoglein-2 (DSG2), partial (Active)

Function

(Microbial infection) Required for fiber protein-mediated Human Adenovirus 55 and 14a infection; via its interaction with fiber protein

Subcellular Location

Secreted

Disease Association

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10) : A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. [The disease is caused by variants affecting the gene represented in this entry] | Cardiomyopathy, dilated, 1BB (CMD1BB) : A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in undifferentiated pluripotent stem cells, expression decreases during differentiation (at protein level) (PubMed:29910125). Expressed in hematopoietic stem cells and circulating endothelial progenitor cells, expression decreases upon increasing cell lineage commitment (at protein level) (PubMed:27338829). Expressed on common myeloid progenitors, pro-myelocytes, pro-erythrocytes and B-cell linage progenitors (at protein level). Expression in mature cell types in the bone marrow and mature leukocyte populations is absent (PubMed:27338829). Expressed by foreskin fibroblasts, expression peaks during the early stage of differentiation reprogramming (at protein level) (PubMed:29910125). Expressed by endothelial cells in both arterioles and venules in the cervix (at protein level) (PubMed:27338829). Expressed in pancreatic alpha-cells, beta-cells and exocrine tissue (at protein level) (PubMed:36309486). Expressed in cardiomyocytes (at protein level) (PubMed:31845994, PubMed:38375917). Expressed in kidney tubular epithelial cells (PubMed:38395410). Expressed in the esophageal mucosa (PubMed:24220297)

Subunit

(Microbial infection) Interacts (via Cadherin 3 domain) with human adenovirus B3 fiber protein (as a homotrimer) (PubMed:29849084, PubMed:30862836). Interacts with human adenovirus 55 fiber protein; the interaction is required for infection of host cells (PubMed:32581096)

• Schaefer S. et al. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. — Exp. Cell Res. (1994)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Koch P.J. et al. Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene. — Eur. J. Cell Biol. (1991)
• Chen X. et al. Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. — J. Biol. Chem. (2002)
• Zhang H. et al. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. — Nat. Biotechnol. (2003)
• Liu T. et al. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. — J. Proteome Res. (2005)
• Olsen J.V. et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. — Cell (2006)
• Cirillo N. et al. The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. — J. Cell. Biochem. (2008)