Recombinant Human Dickkopf-related protein 4 (DKK4), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.2kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Dickkopf-related protein 4 (DKK4)

Recombinant Human Dickkopf-related protein 4 (DKK4) — Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Purity >85%.

SKU: BCRECP-000512 Category:
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Product Specifications

Product SkuBCRECP-000512
Product DescriptionRecombinant Human Dickkopf-related protein 4 (DKK4) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 19-224aa. [Accession | Q9UBT3].
Uniprot No.Q9UBT3
Gene NamesDKK4
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region19-224aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in cerebellum, T-cells, esophagus and lung

Product Specifications

Recombinant Human Dickkopf-related protein 4 (DKK4) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 19-224aa, with N-terminal 6xHis-tagged tag, molecular weight 27.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)

Subcellular Location

Secreted

Tissue Specificity

Expressed in cerebellum, T-cells, esophagus and lung

Subunit

Interacts with LRP5 and LRP6

Gene: DKK4  |  Organism: Homo sapiens

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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