Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 45.1kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial

Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial — Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Purity >85%.

SKU: BCRECP-000505 Categories: ,
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Product Specifications

Product SkuBCRECP-000505
Product DescriptionRecombinant Human Dihydroorotate dehydrogenase (quinone) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 31-395aa. [Accession | Q02127].
Uniprot No.Q02127
Gene NamesDHODH
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region31-395aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight45.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.

Biological Context

Subcellular Location: Mitochondrion inner membrane (Single-pass membrane protein)
Disease Association: Postaxial acrofacial dysostosis (POADS) : An autosomal recessive syndrome characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1

Product Specifications

Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 31-395aa, with N-terminal 10xHis-tagged tag, molecular weight 45.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway

Subcellular Location

Mitochondrion inner membrane (Single-pass membrane protein)

Disease Association

Postaxial acrofacial dysostosis (POADS) : An autosomal recessive syndrome characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Monomer

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1

Gene: DHODH  |  Organism: Homo sapiens  |  Synonyms: Dihydroorotate oxidase
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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