Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 4.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial

Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial — May be required for DNA interstrand cross-link repair. Purity >85%.

SKU: BCRECP-000480 Category:
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Product Specifications

Product SkuBCRECP-000480
Product DescriptionRecombinant Human DNA cross-link repair 1A protein (DCLRE1A) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 690-1040aa. [Accession | Q6PJP8].
Uniprot No.Q6PJP8
Gene NamesDCLRE1A
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region690-1040aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight4.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle

Product Specifications

Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 690-1040aa, with N-terminal 6xHis-tagged tag, molecular weight 4.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986)

Subcellular Location

Nucleus

Tissue Specificity

Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle

Subunit

Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1

Gene: DCLRE1A  |  Organism: Homo sapiens  |  Synonyms: Beta-lactamase DCLRE1A; SNM1 homolog A
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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