Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 39.0kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A)

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A) — DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Purity >90%.

SKU: BCRECP-000107 Categories: ,
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Product Specifications

Product SkuBCRECP-000107
Product DescriptionRecombinant Human DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-199aa. [Accession | P31941].
Uniprot No.P31941
Gene NamesAPOBEC3A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-199aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight39.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA.

Biological Context

Subcellular Location: Nucleus; Cytoplasm
Tissue Specificity: (Microbial infection) Expression in the urothelium is increased upon infection by BK polyomavirus (BKPyV)
Disease Association: [In the urothelium, antiviral activity of APOBEC3A and APOBEC3B against BK polyomavirus (BKPyV) drives a high burden of mutations in cells proximal to infected neighbors (transmutagenesis), and may be involved in urothelial carcinogenesis]

Product Specifications

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-199aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 39.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation

Subcellular Location

Nucleus; Cytoplasm

Disease Association

[In the urothelium, antiviral activity of APOBEC3A and APOBEC3B against BK polyomavirus (BKPyV) drives a high burden of mutations in cells proximal to infected neighbors (transmutagenesis), and may be involved in urothelial carcinogenesis]

Tissue Specificity

(Microbial infection) Expression in the urothelium is increased upon infection by BK polyomavirus (BKPyV)

Subunit

Interacts with AGO2. Interacts with TRIB3 (via N-terminus)

Gene: APOBEC3A  |  Organism: Homo sapiens  |  Synonyms: Phorbolin-1
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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