Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 58.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM)

Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) — Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks. Purity >85%.

SKU: BCRECP-001415 Category:
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Product Specifications

Product SkuBCRECP-001415
Product DescriptionRecombinant Human DNA-directed DNA/RNA polymerase mu (POLM) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-494aa. [Accession | Q9NP87].
Uniprot No.Q9NP87
Gene NamesPOLM
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-494aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight58.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks. Functions as a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Displays reduced sugar discrimination, incorporating deoxyribonucleotides and ribonucleotides with similar efficiency on DNA primer strands, and is able to polymerize nucleotides on RNA-terminated primer strands in vitro.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Predominantly expressed in peripheral lymphoid tissues

Product Specifications

Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-494aa, with N-terminal 6xHis-tagged tag, molecular weight 58.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks (PubMed:10747040, PubMed:10982892, PubMed:12640116, PubMed:12888504, PubMed:17483519, PubMed:17915942, PubMed:26240373). Functions as a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ) (PubMed:12640116, PubMed:17915942, PubMed:26240373). Displays reduced sugar discrimination, incorporating deoxyribonucleotides and ribonucleotides with similar efficiency on DNA primer strands, and is able to polymerize nucleotides on RNA-terminated primer strands in vitro (PubMed:12640116, PubMed:12888504). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination (By similarity)

Subcellular Location

Nucleus

Tissue Specificity

Predominantly expressed in peripheral lymphoid tissues

Gene: POLM  |  Organism: Homo sapiens  |  Synonyms: Terminal transferase

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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