Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 58.7kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial

Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial — Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Purity >85%.

SKU: BCRECP-000383 Categories: , ,
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Product Specifications

Product SkuBCRECP-000383
Product DescriptionRecombinant Human Dual specificity protein kinase CLK2 (CLK2) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 138-499aa. [Accession | P49760].
Uniprot No.P49760
Gene NamesCLK2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region138-499aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight58.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution.

Biological Context

Subcellular Location: Nucleus speckle
Tissue Specificity: Endothelial cells. Expressed in androgen-dependent prostate cancer cells

Product Specifications

Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 138-499aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 58.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210)

Subcellular Location

Nucleus speckle

Tissue Specificity

Endothelial cells (PubMed:19168442). Expressed in androgen-dependent prostate cancer cells (PubMed:28289210)

Subunit

Interacts with RBMX. Interacts with AKT1 and UBL5

Gene: CLK2  |  Organism: Homo sapiens  |  Synonyms: CDC-like kinase 2
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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