Recombinant Human Dynactin subunit 3 (DCTN3), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 35.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Dynactin subunit 3 (DCTN3)

Recombinant Human Dynactin subunit 3 (DCTN3) — Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Purity >90%.

SKU: BCRECP-000483 Category:
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Product Specifications

Product SkuBCRECP-000483
Product DescriptionRecombinant Human Dynactin subunit 3 (DCTN3) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 2-176aa. [Accession | O75935].
Uniprot No.O75935
Gene NamesDCTN3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-176aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight35.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Cycle

Function

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Together with dynein may be involved in spindle assembly and cytokinesis.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle; Cleavage furrow; Midbody
Tissue Specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain

Product Specifications

Recombinant Human Dynactin subunit 3 (DCTN3) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-176aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 35.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614)

Subcellular Location

Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle; Cleavage furrow; Midbody

Tissue Specificity

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain

Subunit

Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin

Gene: DCTN3  |  Organism: Homo sapiens  |  Synonyms: Dynactin complex subunit 22 kDa subunit
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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