Function
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement.
Biological Context
Subcellular Location: Cell membrane; Secreted, extracellular space
Tissue Specificity: Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells
Product Specifications
Recombinant Human Ecto-NOX disulfide-thiol exchanger 2 (ENOX2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 314-610aa, with Tag-Free tag, molecular weight 34.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
