Recombinant Human Endothelin B receptor (EDNRB) Protein, Homo sapiens (Human), in vitro E.coli expression system, C-terminal 10xHis-tagged, 50.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Endothelin B receptor (EDNRB) Protein

Recombinant Human Endothelin B receptor (EDNRB) Protein — Non-specific receptor for endothelin 1, 2, and 3. Purity >90%.

SKU: BCRECP-00603TM Category:
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Product Specifications

Uniprot No.P24530
Gene NamesEDNRB
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region27-442aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight50.3kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized EDNRB at 5 μg/ml can bind human EDN1 with a linear range of 6.25-25.00 μg/ml.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells
Disease Association: Waardenburg syndrome 4A (WS4A) : A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). [The disease is caused by variants affecting the gene represented in this entry] | Hirschsprung disease 2 (HSCR2) : A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. [The disease is caused by variants affecting the gene represented in this entry] | ABCD syndrome (ABCDS) : An autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine. [The disease is caused by variants affecting the gene represented in this entry] | [Heterozygous mutations in EDNRB may be responsible for Waardenburg syndrome 2, an autosomal dominant disorder characterized by sensorineural deafness and pigmentary disturbances]

Product Specifications

Recombinant Human Endothelin B receptor (EDNRB) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 27-442aa, with C-terminal 10xHis-tagged tag, molecular weight 50.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized EDNRB at 5 μg/ml can bind human EDN1 with a linear range of 6.25-25.00 μg/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Waardenburg syndrome 4A (WS4A) : A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). [The disease is caused by variants affecting the gene represented in this entry] | Hirschsprung disease 2 (HSCR2) : A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. [The disease is caused by variants affecting the gene represented in this entry] | ABCD syndrome (ABCDS) : An autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine. [The disease is caused by variants affecting the gene represented in this entry] | [Heterozygous mutations in EDNRB may be responsible for Waardenburg syndrome 2, an autosomal dominant disorder characterized by sensorineural deafness and pigmentary disturbances]

Tissue Specificity

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells

Gene: EDNRB  |  Organism: Homo sapiens  |  Synonyms: Endothelin receptor non-selective type
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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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