Recombinant Human Epoxide hydrolase 1 (EPHX1), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 71.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Epoxide hydrolase 1 (EPHX1)

Recombinant Human Epoxide hydrolase 1 (EPHX1) — Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Purity >90%.

SKU: BCRECP-000596 Categories: ,
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Product Specifications

Product SkuBCRECP-000596
Product DescriptionRecombinant Human Epoxide hydrolase 1 (EPHX1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-455aa. [Accession | P07099].
Uniprot No.P07099
Gene NamesEPHX1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-455aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight71.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.

Biological Context

Subcellular Location: Microsome membrane (Single-pass type III membrane protein); Endoplasmic reticulum membrane (Single-pass type III membrane protein)
Tissue Specificity: Found in liver
Disease Association: [In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls] | [Variations in EPHX1 gene non-coding regions have been observed in a patient with hypercholanemia. The pathogenicity of these variants has not been confirmed]

Product Specifications

Recombinant Human Epoxide hydrolase 1 (EPHX1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-455aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 71.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)

Subcellular Location

Microsome membrane (Single-pass type III membrane protein); Endoplasmic reticulum membrane (Single-pass type III membrane protein)

Disease Association

[In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls] | [Variations in EPHX1 gene non-coding regions have been observed in a patient with hypercholanemia. The pathogenicity of these variants has not been confirmed]

Tissue Specificity

Found in liver

Gene: EPHX1  |  Organism: Homo sapiens  |  Synonyms: Epoxide hydratase; Microsomal epoxide hydrolase
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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