Recombinant Human Estrogen receptor beta (ESR2), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 61.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Estrogen receptor beta (ESR2), partial

Recombinant Human Estrogen receptor beta (ESR2), partial — recombinant protein from Homo sapiens (Human), expressed in Yeast. Purity >90%.

SKU: BCRECP-000610 Category:
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Product Specifications

Product SkuBCRECP-000610
Product DescriptionRecombinant Human Estrogen receptor beta (ESR2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 2-530aa. [Accession | Q92731].
Uniprot No.Q92731
Gene NamesESR2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region2-530aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight61.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTranscription

Function

Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain
Disease Association: Ovarian dysgenesis 8 (ODG8) : An autosomal dominant form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Estrogen receptor beta (ESR2), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 2-530aa, with N-terminal 6xHis-tagged tag, molecular weight 61.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability

Subcellular Location

Nucleus

Disease Association

Ovarian dysgenesis 8 (ODG8) : An autosomal dominant form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain

Subunit

Preferentially forms a heterodimer with ESR1 rather than ESR2 isoform 1 and inhibits DNA-binding by ESR1

Gene: ESR2  |  Organism: Homo sapiens  |  Synonyms: Nuclear receptor subfamily 3 group A member 2
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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