Recombinant Human Eukaryotic initiation factor 4A-II (EIF4A2), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 73.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Eukaryotic initiation factor 4A-II (EIF4A2)

Recombinant Human Eukaryotic initiation factor 4A-II (EIF4A2) — ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Purity >90%.

SKU: BCRECP-000578 Category:
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Product Specifications

Product SkuBCRECP-000578
Product DescriptionRecombinant Human Eukaryotic initiation factor 4A-II (EIF4A2) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-407aa. [Accession | Q14240].
Uniprot No.Q14240
Gene NamesEIF4A2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-407aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight73.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Biological Context

Disease Association: Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures (NEDHSS) : A disorder characterized by global developmental delay, intellectual disability, poor or absent speech, hypotonia, epilepsy, and structural brain anomalies. Inheritance is autosomal dominant or autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Eukaryotic initiation factor 4A-II (EIF4A2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-407aa, with N-terminal GST-tagged tag, molecular weight 73.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

Disease Association

Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures (NEDHSS) : A disorder characterized by global developmental delay, intellectual disability, poor or absent speech, hypotonia, epilepsy, and structural brain anomalies. Inheritance is autosomal dominant or autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 protein Vhs

Gene: EIF4A2  |  Organism: Homo sapiens  |  Synonyms: ATP-dependent RNA helicase eIF4A-2
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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