Function
Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages.
Product Specifications
Recombinant Human Fc receptor-like protein 5 (FCRL5), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 16-851aa, with C-terminal 10xHis-tagged tag, molecular weight 92.7 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications. Explore more Fc Receptor proteins →
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TGFB3 at 2 μg/mL can bind Human TGFBR2 . The EC50 is 6.173-7.152 ng/mL.;Human TGFBR2 captured on Protein A Chip can bind Recombinant Human TGFB3 with an affinity constant of 1.92 nM as detected by MetaSPR Assay (WeSPRTM 200).
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
