Recombinant Human Fibroblast growth factor 1 (FGF1), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 31.8kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Fibroblast growth factor 1 (FGF1)

Recombinant Human Fibroblast growth factor 1 (FGF1) — Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Purity >90%.

SKU: BCRECP-000663 Categories: ,
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Product Specifications

Product SkuBCRECP-000663
Product DescriptionRecombinant Human Fibroblast growth factor 1 (FGF1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 16-155aa. [Accession | P05230].
Uniprot No.P05230
Gene NamesFGF1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region16-155aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight31.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins.

Biological Context

Subcellular Location: Secreted; Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytosol; Nucleus
Tissue Specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle

Product Specifications

Recombinant Human Fibroblast growth factor 1 (FGF1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 16-155aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 31.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107)

Subcellular Location

Secreted; Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytosol; Nucleus

Tissue Specificity

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle

Subunit

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052)

Gene: FGF1  |  Organism: Homo sapiens  |  Synonyms: Acidic fibroblast growth factor; Endothelial cell growth factor; Heparin-binding growth factor 1
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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