Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 44.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein — (Microbial infection) Used by Y. Purity >85%.

SKU: BCRECP-00314TM Category:
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Product Specifications

Uniprot No.P21462
Gene NamesFPR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-350aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight44.5kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

(Microbial infection) Used by Y. pestis as a receptor on human immune cells. Upon infection, Y.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Monocytes (at protein level). Neutrophils

Product Specifications

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-350aa, with N-terminal 10xHis-tagged tag, molecular weight 44.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Used by Y. pestis as a receptor on human immune cells. Upon infection, Y. pestis releases N-formyl peptides that activate FPR1-mediated immune signaling and chemotaxis. This leads to Y. pestis docking on FPR1 via the lcrV needle cap protein of its type III secretion system (T3SS) followed by the delivery of effector proteins into host immune cells, ultimately triggering immune cell apoptosis

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Monocytes (at protein level) (PubMed:25605714). Neutrophils

Subunit

Homodimer (PubMed:24108355). Heterodimer with FPR2 or FPR3; the heterodimerization with FPR2 is potentiated in response to anti-inflammatory agonists such as lipoxin A4 and ANXA1 (PubMed:24108355). Forms a complex with heterotrimeric G(i) protein composed of GNAI1, GNB1 and GNG2 subunits (PubMed:35217703, PubMed:36064945)

Gene: FPR1  |  Organism: Homo sapiens  |  Synonyms: N-formylpeptide chemoattractant receptor; fMet-Leu-Phe receptor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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