Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 44.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein — (Microbial infection) Used by Y. Purity >85%.

SKU: BCRECP-00314TM Category:
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Product Specifications

Uniprot No.P21462
Gene NamesFPR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-350aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight44.5kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

(Microbial infection) Used by Y. pestis as a receptor on human immune cells. Upon infection, Y.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Monocytes (at protein level). Neutrophils

Product Specifications

Recombinant Human fMet-Leu-Phe receptor (FPR1) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-350aa, with N-terminal 10xHis-tagged tag, molecular weight 44.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Used by Y. pestis as a receptor on human immune cells. Upon infection, Y. pestis releases N-formyl peptides that activate FPR1-mediated immune signaling and chemotaxis. This leads to Y. pestis docking on FPR1 via the lcrV needle cap protein of its type III secretion system (T3SS) followed by the delivery of effector proteins into host immune cells, ultimately triggering immune cell apoptosis

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Monocytes (at protein level) (PubMed:25605714). Neutrophils

Subunit

Homodimer (PubMed:24108355). Heterodimer with FPR2 or FPR3; the heterodimerization with FPR2 is potentiated in response to anti-inflammatory agonists such as lipoxin A4 and ANXA1 (PubMed:24108355). Forms a complex with heterotrimeric G(i) protein composed of GNAI1, GNB1 and GNG2 subunits (PubMed:35217703, PubMed:36064945)

Gene: FPR1  |  Organism: Homo sapiens  |  Synonyms: N-formylpeptide chemoattractant receptor; fMet-Leu-Phe receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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