Recombinant Human Folate receptor beta (FOLR2), partial, Homo sapiens (Human), Baculovirus, N-terminal 10xHis-tagged, 27.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Folate receptor beta (FOLR2), partial

Recombinant Human Folate receptor beta (FOLR2), partial — Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Purity >85%.

SKU: BCRECP-000689 Category:
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Product Specifications

Product SkuBCRECP-000689
Product DescriptionRecombinant Human Folate receptor beta (FOLR2) Protein is expressed from Baculovirus with N-terminal 10xHis-tagged. It contains 19-230aa. [Accession | P14207].
Uniprot No.P14207
Gene NamesFOLR2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region19-230aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight27.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor); Secreted
Tissue Specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues

Product Specifications

Recombinant Human Folate receptor beta (FOLR2), partial is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 19-230aa, with N-terminal 10xHis-tagged tag, molecular weight 27.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor); Secreted

Tissue Specificity

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues

Gene: FOLR2  |  Organism: Homo sapiens  |  Synonyms: Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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